Doxorubicin (Adriamycin, Doxil, Rubex)
: The treatment of this drug can come with several side effects. Here are some of the most common things you might
experience, but keep in mind that there may be more side effects that you need to discuss with your doctor
depending on your individual condition.
Doxorubicin has been associated with causing a serious form of heart disease, and even in some cases, fatal
heart failure. Heart disease can occur while undergoing treatment or it might
not show up until a long time after you have discontinued treatment. The possibility of this occurring depends
on the amount of your dose and any other medical problems you might have. Discuss these details with your
physician before proceeding.
This medication may also cause you to have an allergic reaction. If you experience any side effect while or after
taking this drug, try to get medical assistance as soon as possible.
Other common side effects of this medication are blood disorders. Your body may have a reduced ability to stop
bleeding or to fight off infections. Be aware of any unchecked bleeding or bruising when you have begun therapy
with this drug. Also notice any signs of an infection, such as having chills or fever, sore throat, or
this medication is used to treat cancer by slowing down and in some cases even stopping the growth of cancer cells.
Doxorubicin is also called an anthracycline type chemotherapy drug. It can be used alone to treat your cancer or
your doctor may prescribe it with other medications. Some medications are designed to help reduce the side effects.
It is commonly used to treat breast and ovarian cancers as well as other diseases. It is up to the discretion of
your doctor to prescribe this medication for your condition.
In addition, Doxorubicin is a used to treat the following cancers:
head and neck cancer
Gestational trophoblastic cancer (GTC)
non small cell lung cancer
cancer of the thymus
cancer of the adrenal cortex
chronic lymphocytic leukemia
Autoimmune deficiency syndrome (AIDS)–associated Kaposi's sarcoma
Your physician will determine your dosage amount of this medication. The proper dosage may depend on your existing
medical conditions, your body’s size and weight, and your response to therapy. Your doctor or another certified
medical professional will inject you with the drug, slowly administering it into your blood stream over a period of
thirty to sixty minutes.
is not recommended in the following conditions:
measles or flu shots
heart disease associated with
allergy to Doxorubicin or any of its
patients who have low blood
Patients who have already received
the maximum dose allowed during the lifetime of anthracycline drugs (Daunorubicin, epirubicin,
idarubicin, and others) or mitoxantrone.
Mechanism of action (MOA): Doxorubicin prevents the growth of
cancer cells by inhibiting their synthesis of DNA and RNA, a genetic process necessary for reproduction and
growth of cells.
: Doxorubicin is a potent chemotherapy drug that can be potentially harmful when taken with other inappropriate
medicines. Taking certain medications together can decrease the effectiveness of either one, or worsen the side
effects you may experience with either one. You should provide your
doctor with a list of medications that you take in order to determine whether it is appropriate for you to take
this drug. You should not try to manage your own medication regime.
Talk you your oncologist before taking any of these medicines:
a polyene antifungal
immune system inhibitor
- Digoxin, a medication used in the treatment of several
chemotherapy used to stops
the growth of cancer cells
a medication used to treat
irregular heart beat
depressant drug that causes relaxation
, a drug
used to inhibit the
production of acid in the stomach
medication used to treat pain of gouty arthritis
(Cytoxan), a medication of the
alkylating agent family used to treat a variety of cancers
Cyclophosphamide (Cytoxan, Cytoxan, Neosar, Procytox, Revimmune), a drug
used to treat several types of cancers
effects: Despite the beneficial effects of
Doxorubicin in the treatment of many cancers, it can damage non-cancerous cells and cause side effects; the most
common Doxorubicin side effects include:
darkened and dry skin
darkening of fingernails or toenails
Swelling, pain, redness, or peeling of skin on the palms and soles of the
e can cause serious side effects which require immediate medical
attention; contact your doctor immediately if you experience any of these symptoms:
urine or sweat
of breath or difficulty breathing
diarrhea or constipation
bruising or bleeding
and/or pain at the injection site
throat and fever.
1 - ch.oddb.org
santeontario.com (Doxorubicine) Chlorhydrate pour injection
3 - nlm.nih.gov, Doxorubicin