Fluorouracil Injection (Adrucil,
: There are several precautions associated with receiving a fluorouracil injection. It is a potent medication that
is used in the treatment of certain kinds of cancer. Due to the nature of the drug, it can have drastic side
effects on your body.
This drug is not recommended for patients who are pregnant or nursing newborns. This medication can cause harm to
unborn babies and the effect of the medicine through breast milk is not known, but could be an unnecessary risk.
While taking fluorouracil treatments, you should also take the appropriate steps advised by your doctor to avoid
Many patients also experience a risk of severe allergic reactions to this drug. If you have taken fluorouracil
before or have an allergy to any of the ingredients in this drug, you should tell your doctor before you begin the
There are many more side effects which may come as a result of receiving a fluorouracil injection. It can cause
blood cell disorders and diseases of the bone marrow, which increase your risk of unchecked bleeding, easy
bruising, and severe symptoms associated with infection. You should take steps as necessary to avoid some of these
side effects, such as not receiving any live vaccines, avoiding cuts or activities that may bruise
Fluorouracil is a chemotherapy drug developed for the treatment of several types of cancer, including colon cancer
as one of the most common. It is only prescribed by your doctor and will be administered in the doctor’s
Fluorouracil is used mainly in the treatment of the following cancers:
- ovarian cancer
- cervical cancer
- bladder cancer
Your doctor or other health care professional will give you the medication by injecting a vein with the IV
containing this drug. Fluorouracil is given once a day for 5
consecutive days; the therapy is repeated every 28 days. In general, fluorouracil is administered as an intravenous
injection (into a vein). The injection is done in a hospital or a medical center. The medication must be prepared
and administered by specialists in oncology or hematology. Even in absence of serious side effects, a special
monitoring during treatment is necessary.
cases, your doctor may indicate another dosage, depending on your medication condition or your body's response
to the drug. Whatever dosage prescribed, it is important to follow and complete the treatment as recommended by
your doctor. Misusing fluorouracil can lead to serious health problems.
: fluorouracil should always be taken with care and under a physician’s supervision. You should discuss all of your
medical history and current conditions before receiving chemotherapy. If you have experience poor nutrition, blood
disorders, decreased kidney function, or several other physical conditions, your doctor should know about these
Fluorouracil may not be
recommended to you if you have any of the these medical conditions below:
to fluorouracil or any of its ingredients
pregnant or breastfeeding
potentially serious infection
- impaired bone
Mechanism of action (MOA): Antimetabolites are chemical very
similar to normal substances within your cells; they have, however, property to interfere with DNA production.
When used as chemotherapy for cancer, they slow or stop cancer cells and other cells that divide rapidly.
: Other medications have been known to interact negatively with the fluorouracil injection. They can limit the effectiveness of the treatment or they may significantly
increase the risk of you experiencing unfavorable side effects. Some medicines that are not recommended to be taken
during your fluorouracil treatment are certain antibiotics, blood thinners, and warfarin. However, you should tell
your doctor of all the medications you are taking, including over the counter medicines and some herbal products.
It is never a good idea for you to try and monitor your own medication schedule by stopping or starting new
medicines when undergoing chemotherapy treatment. Tell your doctor about all medications you are
Side effects: while attacking cancer cells,
fluorouracil also affects
normal (healthy) cells, which lead to, in certain patients, the following side effects:
nausea and vomiting
low or high blood pressure
drying or darkening of the skin or nails
sensitivity of skin to sunlight
Tingling in the hands or feet
If the side
effects above persist for weeks, contact your oncologist. In addition, contact your doctor if you experience any
of these symptoms:
red skin rash
urination or red urine
bruising or bleeding
of the feet or legs
of the skin or eyes.