Warning: This drug may cause serious blood disorders. Decreased bone
marrow function may cause low blood counts of the red, white and platelets. Your ability to fight infection may
decrease and you may develop anemia and bruise/bleed easier. Tell your doctor if you develop any signs of
infection, as well as easier bruising/bleeding, unusual tiredness and fast/pounding heartbeat.
You will have to have
your blood count monitored regularly, so keep all laboratory appointments.
Indications: Hycamtin is for the treatment of the
cancer of the ovaries and lungs when other medications haven’t been successful. It may also be used alongside
cisplatin to treat cancer of the cervix.
are some other known treatments for this medication, but are not recommended by the manufacturer. Do not use
unless prescribed by your doctor. It may be used for other types of cancer, such as bone cancer.
This medication is
prescribed in two ways, either orally or by injection. If you are prescribed to take it orally you usually
take it once a day for five days. This time is called a cycle. You usually repeat a cycle every 21 days. Your
dosage will depend on your body size, reaction to therapy and laboratory tests.
doctor prescribes Hycamtin to be injected you will use it intravenously. Always read instructions and dosage
instructions before use. If the treatment comes in contact with the skin, wash immediately with soap and
Hycamtin can cause
decreased levels of white blood cells in the blood, which can be dangerous in fragile patients. Although rare,
an overdose of Hycamtin may also lead to kidney problems. If you think you have been given an overdose or you
experience abnormal symptoms, contact your doctor immediately.
fact that Hycamtin is administered in hospital, missing dose is basically difficult if you respect your doctor’s
appointments. Therefore, If for some reasons you cannot go to the hospital for the treatment, contact your
oncologist before the date you are scheduled for the injection. Do not stay home because you are experience side
cause side effects in most patients. Missing a session of the therapy can
affect the entire treatment.
Tell your doctor and pharmacist of all known allergies you have, as you may be allergic to the inactive
ingredients of this medication.
with your doctor about any known immune disorders you have, such as neutropenia. Also tell them about any
blood/bone marrow disorders, kidney disease and liver disease that you have.
may make you dizzy. Do not do any activity that requires you to be alert, such as operating machinery and
women and women planning on becoming pregnant should avoid taking Hycamtin, as it is known to cause birth
defects and sometimes death.
have any immunizations without first consulting your doctor. Don’t have any contact with people that have
recently had the flu vaccination through the nose or the oral polio vaccination. Avoid contact sports and other
vigorous activities as you may be more susceptible to bleeding profusely and bruising more heavily.
Mechanism of action (MOA): Hycamtin belongs to the class of
chemotherapeutic drugs known as topoisomerase type 1 inhibitor. Normally, before a cell divides into two, its
DNA is copied and each daughter cell receives a copy. Hycamtin slows or stops growth of cancer cells by
interfering with their DNA material needed for reproduction.
Interactions: Your doctor should be aware of all medications you
are taking before prescribing you any medication. Do not take anything containing
phenytoin. You should also avoid consuming tumeric as it may cause the drug to be less
Tell your doctor and pharmacist if you are taking any of these medications:
- All other chemotherapy
Side effects: Hycamtin also affects
healthy cells, which lead to, in certain patients, the following side effects:
- mouth sores
stomach or back pain
nausea and vomiting
fatigue or weakness
Unusual fever or chills accompanied by cough or hoarseness
If the side
effects above persist for weeks, contact your oncologist. In addition, contact your doctor if you experience any
of these symptoms:
shortness of breath
fast or irregular heartbeat
sudden low or high blood pressure
severe depression symptoms
unusual bleeding or bruising
numbness, tingling, or burning sensation in the hands or feet
skin problems: hives, rash, itching, etc.
difficulty breathing or swallowing
Swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower