: Hydroxyurea may cause severe and even life-threatening adverse effects. The medication should be given by
physician experienced in chemotherapy drugs to treat sickle cell anemia. The drug should be used cautiously in
obese patients and patients having kidney disease and liver problem (hepatic impairment).
Indications: Hydroxyurea is used to treat sickle
cell anemia by reducing the number of painful crises, as well as reduce the need for as many blood transfusions.
It can also treat melanoma, chronic myelogenous leukemia, and squamous cell carcinoma.
drug is also able to treat cancers such as polycythemia vera and thrombocythemia, but is not recommended by the
manufacturer. Only use this drug under prescription by your doctor.
Dosage: Hydroxyurea comes as in capsule form.
Read all instructions prior to use of this drug. The medication is taken by the mouth once daily with food.
Swallow the pill whole. Do not crush, chew or break apart the capsule. The dosage you take will depend upon your
response to therapy, weight, and laboratory results. Your doctor will monitor your blood count regularly to
avoid a drop. If you do experience low blood count while on this treatment your doctor may stop treatment for a
period of time. Keep all of your appointments with the laboratory to avoid any unsafe drops.
and healthcare professionals should avoid contact with this medication with bare hands. Gloves should be worn
and spills should be handled with paper towels. Pregnant women should avoid any contact with Hydroxyurea, as it
can be absorbed through the skin and inhaled in the lungs.
Storage: It is important to
at room temperature (15-25 ° C), away from heat above 40 ° C, light and moisture. Keep the medication out of the reach of children
. Hydroxyurea and all other drugs should not be used beyond the expiration date printed on the
Overdose: Hydroxyurea can cause a
life-threatening decrease in the number of blood cells in your body. As with any drug,
Hydroxyurea overdose may be dangerous, mainly if taken for long term. In fact, an overdose of Hydroxyurea can
lead to death in fragile patients. Contact your doctor or the poison control center nearest you if you
experience the following symptoms:
- fast or irregular
- shortness of
- unusual bleeding or
- Signs of infection:
fever, sore throat, chills, cough, etc.
take Hydroxyurea and
all medications as prescribed.
In case you forget to
take a dose, take the missed one as soon as you remember it. However, if it is almost time for your next
do not double the next dose to recover the missing, it can be dangerous. Contact your doctor or wait to go back to
your regular schedule. This applies not only to Hydroxyurea
but also any other drug.
Contraindications: All of your
allergies should be known by your doctor and pharmacist. There is some chance of having an allergic reaction to
body may not be able to fight an infection as well while taking this medication. Avoid contact with people that
have known infections as well as wash your hands to avoid one. If you already have any infections, it may be
harder for your system to fight it.
plan to father a child in the future, the effect of this drug on the sperm count is unknown, so talk to your
doctor about all of the possible risks.
women should not take this medication as it can cause serious birth defects and harm an unborn baby. Breast
feeding is not recommended as it can pass through to the baby and harm them.
people may have a higher risk of serious side effects.
Interactions: Certain drugs may cause excessive side effects as
well as make this medication less effective. Didanosine, stavudine and interferon are all known drugs that can
cause interactions with this treatment.
Tell your doctor or pharmacist if you are taking any of these medications:
vaccines: BCG, yellow fever vaccine, etc..
- Ganciclovir, an antiviral drug
- Azathioprine, an immune system
- Barbiturates, depressant drugs that causes relaxation and
, a drug
used to inhibit the production of
acid in the stomach
medication used to treat pain of
(Cytoxan, Cytoxan, Neosar, Procytox,
Revimmune), a drug used to treat several types of cancers
- All other chemotherapy medications.
Side effects: Hydroxyurea not only cancer cells but also
(healthy) cells, which often leads to, in certain patients, the following side effects:
insomnia or difficulty sleepiness
mild nausea and vomiting
tiredness or weakness
Unusual purple, blue, or black discoloration on the nails
If the side
effects above persist for weeks, contact your oncologist. In addition, contact your doctor immediately if you
experience any of these symptoms:
severe depression symptoms
fast or irregular heart beat
shortness of breath
moderate to severe nausea or vomiting
feeling of constriction of the throat
Swelling of feet or lower legs
- sudden low or high blood pressure