Warning: Lupron can cause headaches, pain in the site and several
other symptoms. Cancer patients having a history or at
risk for heart disease should understand that their risk factors for developing a heart attack are increased. Certain male patients can be at higher risk for
developing high blood sugar or diabetes.
Indications: This medication is
used to treat advanced prostate cancer. It is not intended to be a cure. Testosterone is a hormone that the body
produces. It is needed for cancer to grow, this drug works by slowing or stopping the growth of testosterone in
order to slow and stop the growth of cancer.
There are also other known uses for this drug that are not
printed on the drugs professional label, so should only be used by prescription. This medication can be used for
disorders of the uterus in women, such as fibroids and endometriosis, by slowing or stopping the growth of
estrogen. It can also help children with early puberty.
In addition, this medication is used in the treatment of the following medical
- Benign prostatic hypertrophy (BPH)
Dosage:Lupron is given by a healthcare professional, usually once daily,
In the use of this medication for children the
dosage depends on their weight and response to therapy. It is recommended for doctors to stop use of this
treatment in the age of 11 for girls and 12 for boys.
If you are instructed to inject this medication
yourself, read all instruction and safety warnings before treatment. If the dose is discolored or has particles
in it, do not use. Keep using the drug at the same time each day to receive the full benefits of the
Pregnant women should not handle this medication,
as it can be inhaled through the lungs and absorbed through the skin.
Storage:The vials or kits of Lupron should be
refrigerated at a temperature between 2 ° C and 8 ° C, and protected from light. Do not let the drug at the
children reach. After opening, powder and solvent for the solution must be reconstituted and administered
immediately. The physicochemical stability of the reconstituted solution last about 30 minutes at 25 °
Overdose:Lupron overdose is very rare, in fact,
no cases of misuse or overdose has been reported in clinical practice. However, if overdose occurs, medical
attention is very important. In some cases, symptomatic treatment can be recommended.
some reasons you forget a dose or cannot be present at the hospital for the treatment, contact your
oncologist before the date of the appointment. In fact, this case is rarely reported.
Contraindications: Tell your doctor of all
allergies, as you may be allergic to some ingredients in Lupron.
You should tell your doctor and pharmacist of all
your medical history, including, heart disease, diabetes, stroke or family history of sudden cardiac
This drug may cause osteoporosis if used over a
long period of time. Do not use this medication if you have a history of long term alcohol use, smoking, family
history of broken bones or if you are taking corticosteroids, prednisone or phenytoin.
This medication may make you dizzy, do not do
anything that requires alertness, such as driving or operating machinery.
Pregnant women should not take this medication under any circumstance. If you become pregnant
while taking Lupron, tell your doctor immediately.
Mechanism of action (MOA): Your body produces a group of cells
called gonadotropes. Located in the pituitary glands
(hypophysis), those cells produce the gonadotropins
follicle-stimulating hormone (FSH) and luteinizing hormone (LH). FSH and LH are controlled by
gonadotropin-releasing hormone (GnRH), another hormone produced and controlled by the hypothalamus. Certain
cancer cells such as those of prostate and breast cancers need those hormones to survive. Lupron works by
the secretion of gonadotropes.
Interactions: Your pharmacist and
medical professional should already be aware of all the possible interactions this drug may have with the drugs
you are taking. Always tell your doctor and pharmacist of all medications you are taking to avoid any
Tell your health care provider if you are taking of this list:
(Neoral, Restasis, Sandimmune)
Side effects: Lupron damages cancer cells as well as
healthy cell that reproduce rapidly which makes it to cause the following
nausea and vomiting
- diarrhea or
- anxiety or
and concentration problems
drying or darkening of the skin or nails
sensitivity of skin to sunlight
tingling in the hands or feet
- increased need to urinate,
especially at night
tenderness or change in breast size
- incapacity or decrease in sexual
desire in men and women
- decrease in size of
- vaginal discharge, dryness, or
- absence of menstrual periods
- Firmness or hardness at subcutaneous
oncologist immediately if you experience any of these symptoms:
- testicular or prostate
- inability to move arms or
- painful or difficult
painful urination or red urine
unusual bruising or bleeding
swelling of the feet or legs
- signs of heart problems
Yellowing of the skin or eyes
severe depression symptoms
weakness, or pain in the feet or legs .