There are several warnings that a patient should understand concerning Lupron Depot. Participants with metastatic vertebral lesions or urinary tract obstruction
should be closely observed during the initial weeks of administration. Men receiving this treatment have been
reported with hyperglycemia and an increased chance of developing diabetes. Men have also been found to have increased chances of suffering myocardial
infarction, stroke or sudden cardiac death. The risks of these
events must be balanced against the efficacy of the drug against the cancer.
congenital long QT syndrome should understand that this medication works through long-term androgen deprivation
which in turn extends the QT interval. This warning
also targets patients with electrolyte abnormalities, congestive heart failure, or those taking class IA or
Class III antiarrhythmic mediations.
carefully monitor the serum levels of testosterone. Most patients
experience a rise in serum levels above the baseline for the first four weeks of therapy.
Indications: Lupron Depot is
leuprolide acetate, which is a synthetic nonapeptide counterpart of naturally occurring gonadotropin-releasing
hormone (GnRH). The fabricated synthesis is more potent than the
natural hormone. The drug comes ready for administration in a
prefilled dual-chamber syringe. This contains sterile lyophilized
microspheres which are mixed with a diluent to become a suspension suitable for intramuscular
Lupron Depot can be used in the treatment of the following medical conditions:
- Benign prostatic hypertrophy (BPH).
Depot must follow a particular timetable, according to a physician’s specifications. The timing and dosage must not
be altered or the efficacy of the drug is severely compromised. Treatments come in 3 administration periods, 3
month, 4 month, and 6 month. The dosages for these treatment plans are 22.5 mg, 30 mg, and 45 mg, respectively. The
dosages are injections which must be administered every 12 weeks for the 3 month plan, every 16 weeks for the 4
month plan, and every 24 weeks for the 6 month plan.
The vials or kits of Lupron Depot should be refrigerated at a temperature between 2 ° C and 8 ° C, and protected
from light. Do not let the drug at the children reach. After opening, powder and solvent for the solution must be
reconstituted and administered immediately. The physicochemical stability of the reconstituted solution last about
30 minutes at 25 ° C.
Lupron Depot overdose is very rare, in fact, no cases of misuse or overdose has been reported in clinical practice.
However, if overdose occurs, medical attention is very important. In some cases, symptomatic treatment can be
for some reasons you forget a dose or cannot be present at the hospital for the treatment, contact your
oncologist before the date of the appointment. In fact, this case is rarely reported.
This medication is contraindicated in people with known hypersensitivity to GnRH agonists or any of the
excipients of the medication. These have been reported to induce
anaphylactic reactions in some recipients.
For patients who
are pregnant, this drug can cause harm to the fetus. This drug is
contraindicated to patients who are or may become pregnant. The
physician should be careful to inform the patient of the potential hazards of this drug to the
Mechanism of action (MOA): Your body produces a group of cells
called gonadotropes. Located in the pituitary glands
(hypophysis), those cells produce the gonadotropins
follicle-stimulating hormone (FSH) and luteinizing hormone (LH). FSH and LH are controlled by
gonadotropin-releasing hormone (GnRH), another hormone produced and controlled by the hypothalamus. Certain
cancer cells such as those of prostate and breast cancers need those hormones to survive. Lupron Depot works by
the secretion of gonadotropes.
No interaction studies have been performed with Lupron Depot, it is important
tell your doctor about all prescription and nonprescription medications you are taking; the list include but not
limited to aspirin, vitamins supplements, and the following dugs:
(Neoral, Restasis, Sandimmune)
Side effects: attacking cancer cells,Lupron
Depot also affects
normal (healthy) cells, which lead to, in certain patients, the following side effects:
nausea and vomiting
- diarrhea or
and concentration problems
darkening of the skin or nails
depression or anxiety
sensitivity of skin to sunlight
tingling in the hands or feet
- increased need to urinate,
especially at night
- breast tenderness or change in
- decrease in size of
- vaginal discharge, dryness, or
- absence of menstrual periods
- Hardness at subcutaneous injection
- incapacity or decrease in sexual
desire in men and women
If the side
effects above become severe or persist for weeks, contact your oncologist. In addition, contact your doctor
immediately if you experience any of these symptoms:
- testicular or prostate
- painful or difficult
- inability to move arms or
painful urination or red urine
unusual bruising or bleeding
swelling of the feet or legs
Yellowing of the skin or eyes
severe depression symptoms
weakness, or pain in the feet or legs .