Methotrexate can cause very
severe side effects and has caused death on rare occasions. Because of these risks, this medication should only be
used as directed by a doctor for the treatment of certain cancers, as well as severe diseases such aspsoriasis and rheumatoid arthritis that are caused by
overactive immune systems.
Methotrexate can cause death to unborn
babies and can cause severe birth defects. This medication must not be taken if you are pregnant or
breastfeeding, and proper precautions, including contraception, should be taken to insure that you do not become
pregnant while taking this medication.
drug can cause severe bone marrow suppression in rare instances that can restrict your body’s natural ability to
fight off infection and in rare cases can result in fatality. This drug can also cause mild or severe intestinal
bleeding if taken in conjunction with non-steroidal anti-inflammatory drugs (NSAIDS). Consult with your
physician regarding any other possible side effects before taking this medication.
Indications: Methotrexate is a very helpful
treatment for certain types of cancer because it is an antimetabolite drug that is able to block the metabolism
(energy production) of cells, such as abnormal cancer cells. It is also sometimes used to treat psoriasis and to
induce miscarriages in rare situations like ectopic pregnancy. It is also used for the treatment of rheumatoid
arthritis, although it is not currently known exactly what mechanism it uses to treat this
this medication is normally well-tolerated, it can sometimes cause mild symptoms and on rare occasions may cause
very severe symptoms. Some of the possible mild symptoms that this medication may cause include dizziness,
headaches, upset stomach and nausea, hair loss, mouth sores and skin rash. Some rare severe symptoms include
kidney, liver, lung, or bone marrow toxicity. If you experience any mild or severe symptoms from taking this
medication, inform your physician immediately.
Never exceed dosage instructions for this medication, as doing so could result in severe symptoms or even fatality
in rare circumstances. Your physician will give you dosage instructions based on your specific needs, and those
dosage instructions should be followed exactly. Your physician will closely monitor your blood, liver, and kidney
functions to determine if your dosage needs to be raised, lowered, or discontinued. The medication may be
taken with or without food, depending on your physician’s specific instructions.
Methotrexate can be taken several
- by mouth, in pill
infusion (into the vein IV)
injection (into the muscle)
infusion (within a ventricle)
- Intrathecal infusion
(inside the spinal canal).
when methotrexate is given in hospital by professionals, the risk of overdose is almost nonexistent; however,
accidental overdose or administrative mistake can happen. When the drug is taken by mouth chance of overdose
increases. An overdose of methotrexate can cause a decrease in the number of blood cells in your bone marrow, which
can lead to severe health problems and even death. Even in absence of therapeutic overdose, Methotrexate
intoxication can lead to:
- damage to the lining
of the mouth, stomach or intestines
- severe skin reactions
- lung Infections such
- bone and soft tissue
- severe damage to the
liver, kidney, lungs, and gastrointestinal tract
- lymphoma, a cancer
that rises in the lymphocytes of the immune system
- Tumor lysis syndrome, a
life-threatening complication of cancer treatment.
experience any symptom that may indicate presence of these
medical conditions, contact your physician or emergency clinic/hospital as soon as possible. Even in the absence
of signs, it is important to see your doctor regularly during the treatment; do not neglect the appointments
with your doctor and the laboratory.
methotrexate is given by injection, it is administered in hospital; missing dose is basically difficult if you
keep all your doctor’s appointments. If for some reasons you cannot be present at the hospital for the
treatment, contact your health care provider before the date scheduled for the injection.
are recommended to take methotrexate by mouth in tablet form, it may happen you forget to take it. If you miss a
dose, take it as soon as you remember it if it is not almost time to take the next dose. If you forgot to take
the medicine, and it is almost time for the nest dose, wait for the next one; in any case, do not double the
Contraindications: Do not take this medication if you currently
have, or have a history of excess body water fluid retention in the stomach area or around the lungs without
first consulting your physician. The medication is not recommended to patients who have severe kidney
The medication is contraindicated or should be used with precaution in the following medical
- alcohol consumption
- low number of blood
to methotrexate or any of its ingredients
to antimetabolites in general
infants or children should be treated with methotrexate only under medical supervision.
Do not take this medication in conjunction with non-steroidal anti-inflammatory drugs and notify your physician
of any other medications you are currently taking before taking Methotrexate.
Side effects: methotrexate not only attack cancer cells but
cells, which often leads to, in most patients, the following side effects:
- dry skin
- decreased appetite
- trouble sleeping
- Mild nausea and vomiting
If the side
effects above persist for weeks, contact your oncologist. In addition, contact your doctor immediately if you
experience symptoms that indicate:
Damage to the liver, heart or lung: persistent nausea, extreme
tiredness, pain in the upper right part of the stomach, dry cough, fast and irregular heartbeat, fever,
shortness of breath or any flu-like symptom.
Damage to the lining of the mouth,
stomach or intestine: mouth sores, persistent diarrhea,
black, tarry or bloody stools, sore throat, or bloody vomitting.
Damage to the skin or
pain, fever, rash, blisters, peeling skin, yellowing of the skin or eyes, or
purple, blue or black discoloration of the skin.
: anxiety, severe depression symptoms,
dehydration, nose bleeding, vision changes, red itchy eye, or intense headaches.