Warning: Mitotane is a
medication that suppresses the action of your body’s adrenal glands, so you won’t be able to react normally to
stress, injury, shock, or trauma. Your body will not be able to produce adequate amounts of the hormone cortisol,
so if you do experience shock, injury, infection, or trauma, your doctor may prescribe a different medication. Your
doctor may also choose to discontinue your Mitotane treatment.
most frequently prescribe Mitotane as part of a course of treatment for cancer of the adrenal glands that can‘t
be treated with surgery; the medication works by suppressing the hormone production of the adrenal glands or
stopping or slowing the growth of cancer cells. The adrenal glands
are responsible for releasing hormones into the body. Hormones help
maintain normal body function, as well as fight infection and control stress. This is why it is very important that your doctor be told if you experience
any injury or shock while taking Mitotane.
is also used to treat other conditions related to excess hormone production, such as Cushing’s
Dosage: Mitotane comes as a tablet to be taken by mouth. However, the treatment will begin in a hospital or clinic
setting so your doctor can monitor your response to the drug. Once
it has been determined what dose is best for you, your doctor will allow you to continue taking it on your own.
The fact that Mitotane comes in tablet form, patients should swallow each dose with a glass of
water. Most patients taking Mitotane will take three to four
doses each day; you may take it with or without meals, or as your doctor has instructed.
Even if you
feel better, you should continue to take Mitotane. It is very
important to follow the dosing instructions exactly. Don’t increase the amount you take or take it more
frequently. You should also not skip any doses or stop taking the medication unless your doctor has told you
Storage: store Mitotane
at room temperature (15-25 ° C), away from heat, light and moisture. Always keep your medications out of the reach of children
and all drugs should not be used beyond the expiration date printed on the container.
Overdose: it is very important that you
Mitotane as indicated by your health care provider. Regardless of the circumstance, do not take Mitotane more often. Even when
taken at normal dose
, Mitotane can reduce the amount of steroid hormones (cortisol) synthesized by the adrenal cortex, which can lead
to the development of life-threatening conditions. If you think you have taken an overdose, contact your doctor or
the poison control center nearest you as soon as possible.
Mitotane as indicated your doctor or pharmacist.
In case you forget to
take a dose, take the missed one as soon as you remember it. However, if it is almost time for your next
do not double the next dose to recover the missed one; it can be dangerous. Contact your doctor or wait to go back
to your regular schedule.
There are certain health conditions that contraindicate the use of
Mitotane. You need to tell your doctor if you have recently had any
kind of viral infection such as herpes (including cold sores) or chicken pox. Tell your doctor if you are allergic to any medications, including Mitotane or
any of its inactive ingredients. Also, be sure to tell your doctor
if you have or have had any of the following conditions: Liver
disease; pregnancy; if you may become pregnant; producing milk or breastfeeding; or high blood pressure problems. This is not a
complete list of contraindications, so you should talk to your doctor about any concerns you
Mechanism of action (MOA): Mitotane is an antineoplastic agent
that works by reducing the amount of steroid hormones synthesized by the adrenal cortex, which slows or stops
division or reproduction of cancer cells that need these hormones to survive.
There are a number of drugs known to interact with Mitotane. This
includes (but isn’t limited to) “blood thinners” such as warfarin, diuretics, “water pills”, and corticosteroids
such as dexamethasone and prednisone. Also, tell your doctor if you
are taking any medication that can cause drowsiness. This
potentially includes antihistamine, muscle relaxants, psychiatric medications, anti-seizure drugs, and narcotic
Side effects: in certain
patients, Mitotane can lead to
- insomnia problems
- decreased appetite
- unusual drowsiness
or changes in skin color
If the side
effects above persist for weeks, contact your oncologist. In addition, contact your doctor if you experience any
of these symptoms:
- severe clinical depression
anxiety or confusion
of heart health or abnomal heartbeat
or side pain
fever or shaking chills
sweating, mainly at night
blue, or black discoloration of the skin.