is a serious disease that can result in many complications; the most common include:
- Anemia - uncontrolled growth of myeloma cells may cause
decreased production of blood platelets and inhibition of normal red blood cells.
normally, the role of anti bodies (immunoglobulins) is to fight infection; however, presence of antibodies
in very large amounts (myeloma cells) inhibits the synthesis of other normal immunoglobulins, which no
longer allow the body to cope with infectious agents. Although the list of infection that can be due to a
weakened immune system is enormous, the most common infections that are related to myeloma are pneumonias
and urinary tract infection (UTI).
- multiple myeloma can also lead to neurological disorders such as confusion and fatigue, severe headache,
visual changes and retinopathy, and other problems of the peripheral nervous system. In severe cases, you may
loss of bowel control
carpal tunnel syndrome
disorders - myeloma
complications can lead to kidney problems including kidney failure. Kidney problems can be due:
high level of uric acid
in the blood (hyperuricemia)
elevated calcium level
in the blood (hypercalcemia)
of fibrous protein in your blood
Tubular damage from
excretion of monoclonal globulin protein.
Bone disorders - problems such as bone pain, fractures, vertebral
collapse are commonly associated with myeloma. Without appropriate treatment, paralysis in the legs can occur.
In addition, dissolving of bone can also cause release of high levels of calcium in the blood, leading to
hypercalcemia and its symptoms: