Warning: In certain instances, Novantrone has
been shown to increase or cause serious heart damage. This can occur directly after the treatment or years down
the road. Also, this medication has shown to have a link to causing secondary leukemia.
Indications: Novantrone is meant for those that are suffering from
certain types of cancer or to help slow or ease the symptoms caused by Multiple Sclerosis. In either of these
cases, the effects of the advanced stages of the disease can be dire. Cancerous cells that grow unharnessed
eventually start to become malignant and attack the body, thus causing extreme amounts of pain and often death.
MS is often characterized by a gradual onset of less mobility and other types of symptoms, which create and
increase disability in individuals. To help slow the symptoms, as well as slow or stop the growth of cancerous
cells, Novantrone uses mitoxantrone to help bolster healthy cells as well as the body’s natural
This medicine is frequently
used with chemotherapy or other types of treatments in order to increase effectiveness of treatment. Common
cancers treated with Novantrone include:
lymphoma (cancer of lymph cells)
types of leukemia (cancer of white blood cells)
hormone-resistant prostate cancer, in
combination with low doses of oral corticosteroids.
Novantrone is also used to treat
Multiple sclerosis (MS). In addition to the
conditions mentioned in the article, Novantrone can be prescribed for other health problems. Talk to your doctor
or pharmacist for more information.
Dosage: This medication is directly injected into a vein in the
arm. It is not meant to come in contact with skin or anything besides the bloodstream. The frequency of
injections for this medication, hence the dosage, will be up to the discretion of the doctor. The prescribed
dosages and lengths will depend largely on the size of an individual, their prior state of health, as well as
any other medications that are being taken. On average, this medication is injected into patients once about
every three months for about two to three years. This figures into about 12 doses maximum, though the term may
be longer or shorter depending on what the doctor prescribes.
Overdose: As with any drug, Novantrone overdose
can be dangerous. Even at normal dose, Novantrone can severely damage the bone marrow, and cause a decrease in
white blood cells and platelets. Novantrone may also cause kidney damage and /or serious heart problems, even
years after the treatment has ended. In fragile patients, Novantrone can lead to death. Although rare,
Novantrone increase the risk for developing leukemia in some patients. The risk is higher when the drug is taken
in high dose or in combination with other chemotherapy medications.
adverse effects vary from one patient to another; no physician can tell how your body is going to react to
Novantrone. Therefore, to reduce the risk of complications, avoid anything that might weaken your immune system
and the risk of infection. During the treatment, keep all appointments with your doctor. Contact your doctor
immediately if you experience any symptom that indicates complications (see side effects below).
Interactions: There is not a full
list of medicines that this medication is or is not compatible with. For those that are under consideration for
taking this medication, make sure to tell your doctor about any other types of medications you are currently
taking or treatments undergone in the past. The effectiveness of this medication is quite dependent on what
other medications are present in an individual’s system. These medications may also have an effect on which
symptoms of Novantrone present themselves.
Contraindications: This medication should not be used on those who have
heart problems, may have heart damage, or any other type of blood-related disease or
disorder (such as anemia). This medication should also not be used on those that will not be able to keep a
regular schedule of dosages, as this may prove extremely serious or even fatal.
Side effects: Novantrone not only attack cancer cells but also non
malignant cells, which
often leads to adverse effects in most patients; most common Novantrone side effects include:
discoloration of urine
- temporary hair loss
in the mouth and lips
whites of the eyes
If the side
effects above persist for weeks, contact your oncologist. In addition, contact your doctor immediately if you
experience any of these symptoms:
unusual bleeding or bruising
small red or purple dots on the skin
infection signs: hives, itching, rash, etc.
shortness of breath
yellowing of the skin or eyes
abnormal or sudden low or high blood pressure
persistent abnormal heartbeat
Redness, pain, swelling, burning, or blue discoloration at the site where the injection was