Warning: Reclast (Zoledronic acid) is associated
with the risk of kidney (renal) failure. Although rare, serious kidney failure has been associated with the use of
Reclast in patients with a history of or risk factors for kidney problem. Cases of acute renal failure requiring
dialysis or having a fatal outcome following Reclast use have been reported to FDA. Tell your health care
provider if you have any history of kidney disease before undergoing the treatment.
This drug is for the
treatment of a specific bone disease (Paget’s disease) and osteoporosis in men, and in women after menopause. It
also may be used in people that need to take corticosteroids over a long period of time to prevent osteoporosis.
It works by slowing bone loss and keeping bones strong. It also reduces the chance for broken bones. This
medication belongs to a class known as bisphosphonates.
is used to treat hypercalcemia (high blood calcium) caused by cancer with or without metastases. The drug is
also used as prevention of complications (fracture of a bone, or bone pain that requires surgery or
radiotherapy) due to the spread of cancer to bones (bone metastases) from different types of
with the medication, you may be recommended to take calcium supplement and a multivitamin containing vitamin D
to prevent bone damage. Reclast may be recommended for other medical conditions that are not mentioned in this
article; talk to your doctor or pharmacist for more information.
Reclast is given
intravenously slowly over 15 minutes, by a healthcare professional. The dose you are given depends on your
body size, medical condition and response to therapy. The maximum dose for adults is 5 milligrams.
drink normally on the day of treatment. Drink 2 full glasses of fluid before treatment, unless otherwise
prescribed by your doctor. It is important to take in plenty of fluids while taking this drug.
doctor may want you to take calcium and vitamin D supplements while taking this medication. If you suffer from
Paget’s disease you should take these 2 weeks after your treatment. Vitamin D and calcium are important to take
to prevent low levels of calcium in the blood. Tell your doctor immediately if you suffer from any signs of low
calcium, such as numbing/tingling (especially in the mouth/lips), and muscle spasms.
medication of Paget’s disease Reclast is given once and then repeated depending on your symptoms. For
osteoporosis it is given once a year.
Reclast must be given
exactly as directed by a health professional that has experience in chemotherapy drugs. In fact, not only
zoledronic acid, but taking any medication in the right dose is the first step to better treatment. An
overdose of Reclast may cause serious kidney problems. Contact your doctor immediately if you experience
these warning signs of overdose:
tightening of muscles
cramps or/and weakness
pounding, or irregular heartbeat
walking or/and speaking
burning, or tingling in fingers or toes.
Contraindications: Before you
start this medication tell your doctor if you are allergic to bisphosphonates such as alendronate or
risedronate, or if you have any wheezing (trouble breathing) after taking aspirin, or of any known allergies
that you have.
use tell your doctor of your medical history, including kidney problems, problems taking vitamin D or calcium,
low calcium levels in the blood, recent or planned dental surgery, gut problems (malabsorbtion, surgery of the
small intestine), treatment with zoledronic acid (for cancer), parathyroid/thyroid problems, and dehydration
(severe loss of water).
Interactions: Keep a list of all medications you are taking. Your
doctor and pharmacist should know of all possible interactions.
products are known to cause interactions with this medication, such as mineral supplements (e.g. calcium,
magnesium, and phosphorous), water pills (diuretics such as bumetanide, furosemide, and
should also tell your doctor if you are taking any medications that can harm your kidneys, such as
aminoglycoside antibiotics, amphotericin B, cyclosporine, nonsteroidal anti-inflammatory durgs, tacrolimus, and
In addition to attacking cancer cells, Reclast
also affects some normal cells and cause adverse effects in most patients. Most
side effects include
bone or joint pain
white vaginal discharge
loss of appetite
loss of weight
nausea and vomiting
difficulty falling asleep or staying asleep
white patches in the mouth
redness of the eye or excessive tearing
redness or swelling at the injection site
Numbness, burning, or tingling in fingers or toes
the side effects above persist for weeks, contact your oncologist. In addition, contact your doctor if you
experience any of these symptoms:
or swollen gums
healing of the
of the teeth
high blood pressure or irregular heartbeat
- numbness or the
feeling of heaviness in the jaw
- signs of
infections: rash, hives, itching, fever, sore throat
of the eyes, face, lips, tongue and/or throat
of the hands, arms, feet, ankles, and/or lower legs
breathing or swallowing
or tingling around the mouth
tightening of muscles
bruising or bleeding.