Rheumatrex (Trexall, Methotrexate)
Warning: Rheumatrix is a
powerful drug that is used to treat some types of cancer and other serious illnesses. Because it is very powerful, there are certain side effects and warnings that
need to be followed when taking this drug. One of the most important
warnings to follow is to avoid this medication if you are pregnant of plan on becoming pregnant. Rheumatrex has been shown to cause serious birth defects and even death in unborn
problems are also associated with prolonged use of this drug, so it will be important for you to drink large
amounts of water to keep yourself hydrated and to see a doctor for liver biopsies if you are on the drug for an
taken at high dosages, Rheumatrix has been shown to cause severe bone marrow suppression and even stomach and
intestinal diseases. These usually occur when the drug is taken at
the same time as a non steroidal, anti-inflammatory drug.
there are other side effects that can be caused by using Rheumatrix, so it will be crucial that you speak to
your physician before you start taking the drug.
Rheumatrix is typically used to treat certain types of cancer, although it can also be effective for treating other
severe conditions like psoriasis and rheumatoid arthritis. The
mechanism of action for this drug is inhibition of cellular growth and suppression of the immune system.
Common Cancers the drug is used to treat
and neck cancer
- stomach cancer
- non-Hodgkin's lymphoma
- gestational trophoblastic
cancer of theesophagus)
osteosarcoma ( a common form of bone cancer)
- Cutaneous T-cell lymphoma (also
known as mycosis fungoides).
Rheumatrex is also used to treat
certain non-cancerous conditions such as psoriasis, rheumatoid arthritis, polymyalgia rheumatica (PMR) and
Crohn's disease. Talk to your doctor or pharmacist for more information.
Dosage: Rheumatrex can be taken several ways:
- by mouth, in pill
infusion (into the vein IV)
injection (into the muscle)
infusion (within a ventricle)
- Intrathecal infusion
(inside the spinal canal).
is no real recommended universal dosage for Rheumatrix. This is
because the dosage will depend on the medical condition that you are trying to treat and your response to the
therapy. Rheumatrix has a variety of different dosing schedules, so
it will be important for you to consult your doctor before you start taking this drug.
when patients taking the medication in hospital by professionals, the risk of overdose is almost nonexistent.
When the drug is taken at home, chance of overdose increases considerably. An overdose of Rheumatrex can cause a
decrease in the number of blood cells in your bone marrow, which can lead to severe health problems and even death.
Even in absence of therapeutic overdose, Rheumatrex intoxication can lead to:
- damage to the lining
of the mouth, stomach or intestines
- severe skin reactions
- lung Infections such
- bone and soft tissue
- severe damage to the
liver, kidney, lungs, and gastrointestinal tract
- lymphoma, a cancer
that rises in the lymphocytes of the immune system
- Tumor lysis syndrome, a
life-threatening complication of cancer treatment.
Missing dose: all
medications should be taken exactly as precribed. If for some reasons you cannot be
present at the hospital for the treatment, contact your health care provider before the date scheduled for the
injection. If you
are recommended to take Rheumatrex by mouth in tablet form, it may happen you forget to take it. If you miss a
dose, take it as soon as you remember it if it is not almost time to take the next dose. If you forgot to take
the medicine, and it is almost time for the nest dose, wait for the next one; in any case, do not double the
Make sure to tell your doctor about any allergies that you have before starting this or any other
medication. As mentioned above, you want to make sure that you are
not pregnant, and that you do not become pregnant while taking this medication.
In general, Rheumatrex is contraindicated or should be used with precaution in the following
- alcohol addiction
- excess fluid in the
stomach area or around the lungs
- low number of blood
to Rheumatrex or any of its ingredients
to antimetabolites in general
infants or children should be treated with Rheumatrex only under medical supervision.
As with most
powerful drugs, other chemicals can change the effects that the drug has on your body. There are some severe interactions that can cause very serious side effects
and even death as with most prescription medications. You will want
to make sure that you tell your doctor about any drugs that you are currently taking so he or she can minimize
the risk of a serious interaction. Some of the drugs that you will
want to be certain to avoid are natalizumab, acitretin, ciprofloxacic, asparaginase, digoxin, penicillins,
procarbazine, theophylline, and phenytoin.
Side effects: Rheumatrex not only attack cancer cells but also
cells, which often leads to, in most patients, the following side effects:
- decreased appetite
- trouble sleeping
- Mild nausea and vomiting
You need to
immediately see your health care provider if you experience symptoms that indicate:
Damage to the liver, heart or lung: persistent nausea, extreme tiredness,
pain in the upper right part of the stomach, dry cough, fast and irregular heartbeat, fever, shortness of breath or
any flu-like symptom.
Damage to the lining of the mouth,
stomach or intestine: mouth sores, persistent diarrhea,
black, tarry or bloody stools, sore throat, or bloody vomitting.
Damage to the skin or
pain, fever, rash, blisters, peeling skin, yellowing of the skin or eyes, or
purple, blue or black discoloration of the skin.
: anxiety, depression, dehydration, nose bleeding, vision
changes, red itchy eye, or intense headaches.