Genetic Mutations that Increases the Risk for Breast Cancer

The researchers analyzed the medical and genetic data from 154 families in eight countries, and made some serious discoveries which shed more light on the nature of breast cancer.

Breast cancer is the most diagnosed cancer among women worldwide, both before and after menopause cancers. 1 in 9 women will be diagnosed with breast cancer during her lifetime and 1 in 27 women will die. The main risk factors essentially involved in the development of the disease are obesity, physical inactivity, alcohol consumption and taking hormone replacement therapy at menopause.

We now know that certain substances play a key role in the occurrence of this cancer. For example, it is estimated that there are at least 17 high carcinogens that have been identified. Among them are chemicals in gasoline, diesel and other vehicle exhaust substances and flame retardants, solvents, stain removal products, Paint Strippers& Removers, and disinfectant derivatives used in the treatment of drinking water. But scientist have also suspected genetic mutations in the development of breast cancer

We knewthat in terms of breast cancer, certain genetic mutations multiplied by seven theprobability of a person being a victim of a tumor. And if the genes had already been identified, the list is about to grow. Researchers have indeed discovered new genetic mutations that increase the probability of 35% of cancer in non-infected women variations BRCA1 / 2, alreadyknown to increase the risk. Their work was published Aug. 7 in The New England Journal of Medicine (in English).

A small proportion ofwomen affected  

The newmutation affects a gene called PALB2. The researchers analyzed the medical and genetic data from 154 families in eight countries, including 362 women were carriers of mutations in thisgene.

“Since the discovery of BRCA1 and BRCA2 in the mid-1990s, no other gene of similar importancefor breast cancer had been discovered,” said Dr. Marc Tischkowitz, Department of Medical Genetics Cambridge University in the UK, lead author of the study.

Only a very small proportion of women worldwide are carriers of these mutations in the PALB2gene and the authors of the study stressed that further research is needed to learn more.

Leave a Reply