According to many studies in mice and rats it seems that cannabinoids may have an anticancer effects against several types of cancers. During a 2-year study, several mice and rats were treated by different doses of THC by gavage. A considerabledecrease in the incidence of liver cancer and adenoma hepatocellular carcinoma (HCC) were observed among those rats and mice. The cannabis works not only against malignant tumors but also against non-cancerous tumors (benign tumors) in different organs such as mammary gland, uterus, pituitary, testis and pancreas.
In other various medical studies, delta-9-THC, delta-8-THC and cannabinol (also an active component found in Cannabis sativa and Cannabis indica (both strains are commonly known as medical marijuana) were shown to reduce the growth of lewis lung carcinoma cells in vitro and in vivo. In addition, many other types of tumors have proven to be sensitive to the inhibition of growth induced by cannabinoids. As some people say, it seems cannabis may work to effectively fight all types of cancer and some other medical conditions considered as incurable by the medical elite.
When it comes to fight cancer, it is shown that cannabinoids perform its anti-tumor effects of various mechanisms,including the induction of cell death, inhibition of cell growth, and inhibition of tumor invasion and angiogenesis metastasis, without causing side effects like the conventional therapies: radiation therapy and chemotherapy for instance. The mode of action of cannabinoids is to kill tumor cells without affecting their non-transformed counterparts and may even protect them from cell death.
Cannabinoids is also an effective pain killer through its anti-inflammatory mechanism. It does so by acting on mast cell receptors to attenuate the release of inflammatory agents (histamine and serotonin), and on keratinocytes in order to enhance the release of analgesic opioids. In fact, the pain killing effect of marijuana is so effective that a recent study has indicated that the efficacy of synthetic CB1- and CB2-receptor agonists were comparable with the efficacy of morphine in a murine model of tumor pain. Wow!
Although there are numerous studies still going on, all over the internet (including on Youtube) individuals continue claiming their success in curing diseases that made their life a living hell before using medical marijuana. The way it seems to be more effective is by using in concentrate oil form (Rick Simpson Protocol). Rick Simpson is considered as the father of this method. Go on Youtube and type Rick Sympson Cannabis Oil for more information
- Adams IB, Martin BR: Cannabis: pharmacology and toxicology in animals and humans. Addiction 91 (11): 1585-614, 1996. [PUBMED Abstract]
- Grotenhermen F, Russo E, eds.: Cannabis and Cannabinoids: Pharmacology, Toxicology, and Therapeutic Potential. Binghamton, NY: The Haworth Press, 2002.
- National Toxicology Program: NTP toxicology and carcinogenesis studies of 1-trans-delta(9)-tetrahydrocannabinol (CAS No. 1972-08-3) in F344 rats and B6C3F1 mice (gavage studies). Natl Toxicol Program Tech Rep Ser 446 (): 1-317, 1996. [PUBMED Abstract]
- Bifulco M, Laezza C, Pisanti S, et al.: Cannabinoids and cancer: pros and cons of an antitumour strategy. Br J Pharmacol 148 (2): 123-35, 2006. [PUBMED Abstract]
- Sánchez C, de Ceballos ML, Gomez del Pulgar T, et al.: Inhibition of glioma growth in vivo by selective activation of the CB(2) cannabinoid receptor. Cancer Res 61 (15): 5784-9, 2001. [PUBMED Abstract]
- McKallip RJ, Lombard C, Fisher M, et al.: Targeting CB2 cannabinoid receptors as a novel therapy to treat malignant lymphoblastic disease. Blood 100 (2): 627-34, 2002. [PUBMED Abstract]
- Casanova ML, Blázquez C, Martínez-Palacio J, et al.: Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors. J Clin Invest 111 (1): 43-50, 2003. [PUBMED Abstract]
- Blázquez C, González-Feria L, Alvarez L, et al.: Cannabinoids inhibit the vascular endothelial growth factor pathway in gliomas. Cancer Res 64 (16): 5617-23, 2004. [PUBMED Abstract]
- Guzmán M: Cannabinoids: potential anticancer agents. Nat Rev Cancer 3 (10): 745-55, 2003. [PUBMED Abstract]
- Blázquez C, Casanova ML, Planas A, et al.: Inhibition of tumor angiogenesis by cannabinoids. FASEB J 17 (3): 529-31, 2003. [PUBMED Abstract]