The causes leading to the development of neuroblastoma are not well known. In fact, in most cases of neuroblastoma, a cause is never identified. However, scientists believe that genetics may play a role in a form of neuroblastoma called “Familial neuroblastoma”. A germline mutation in the anaplastic lymphoma kinase (ALK) gene is suspected in the development of familial neuroblastoma.
Some scientists also suggest that certain allergic hypersensitivity (atopy) and infection early in life can neuroblastoma.