Incidence of squamous cell carcinoma is increasing. It is the most common skin cancer after basal cell carcinoma, which is the first most common form of nonmelanoma skin cancer. Squamous cell carcinoma prevalence rates tend to vary from one country to another. The highest incidence of the disease occurs in Australia; age-adjusted incidence has been estimated to be 1332 cases per 100,000 population for men and 755 cases per 100,000 population for women.
In the United States, annual incidence of Squamous cell carcinoma ranged from 81-136 cases per 100,000 population for men and 26-59 cases per 100,000 population for women. It is estimated that one in five Americans will develop skin cancer in his lifetime. Every year, more than 250,000 people are diagnosed with Squamous cell carcinoma in the United States; approximately 2,500 die of the disease.